Value of early diagnosis and prognosis assessment of serum sCD 40L and NT‐proBNP levels detection in aged patients with heart failure / 心血管康复医学杂志

ABSTRACT

Objective:To study application value of serum sCD40L and NT‐proBNP levels detection in early diagnosis and prognosis assessment of aged patients with heart failure (HF).Methods:A total of 73 aged HF patients treated in our hospital from Feb 2015 to Feb 2017 were selected as HF group .According to NYHA cardiac function class , HF group was divided into class Ⅱ group (n＝37) and class Ⅲ group (n＝36).A total of 112 healthy people ,who had a physical examination in our hospital at the corresponding period ,were selected as health group .HF group were treated for one month .Incidence of major adverse cardiovascular events (MACE) within one‐month was re‐corded .According to MACE during one‐month follow‐up ,HF group was divided into MACE group (n＝20) and no MACE group (n＝53).Serum levels of sCD40L and NT‐proBNP were measured and compared between HF group before treatment and health group ;class Ⅱ group and class Ⅲ group before and after treatment ;MACE group and no MACE group .Results:There were significant rise in serum levels of sCD 40L and NT‐proBNP in HF group be‐fore treatment compared with health group , P＝0. 001 all.Compared with before treatment ,there were significant reductions in serum levels of sCD40L and NT‐proBNP in class Ⅱ group and class Ⅲ group , P＝ 0.001 all.After treatment ,compared with class Ⅲ group there was significant reduction in serum level of sCD40L [ (8.31 ± 0.76) ng／ml vs .(7.37 ± 0.81) ng／ml] in class Ⅱ group , P＝0. 001. During one‐month follow‐up ,20 cases of MACE oc‐curred in HF group (n＝73) and incidence of MACE in HF group was 27.40% .Compared with MACE group ,there were significant reductions in serum levels of sCD 40L [ (10.26 ± 1.54) ng／ml vs.(11. 49 ± 1. 81) ng／ml] and NT‐proBNP [(612. 28 ± 122. 76) ng／L vs.(1072.25 ± 245.68) ng／L] in no MACE group ,P＝0. 001 all.Conclusion:Se‐rum sCD40L and NT‐proBNP levels detection possesses good application value in early diagnosis and prognosis assess‐ment for aged patients with HF ,which is worth extending .