Therapeutic effect of metoprolol tartrate on UAP and its influence on levels of blood lipids and inflam‐ matory factors／ / 心血管康复医学杂志

ABSTRACT

Objective:To observe therapeutic effect of metoprolol tartrate on unstable angina pectoris (UAP) and its influence on levels of blood lipids and inflammatory factors .Methods:A total of 96 UAP patients treated in our hos‐pital from Jan 2016 to Jun 2017 were randomly and equally divided into routine treatment group and metoprolol group (received metoprolol tartrate based on routine treatment ) ,both groups were continuously treated for 14d. Onset times and duration of angina pectoris ,visual analogue scale (VAS) score for pain degree ,levels of blood lip‐ids ,serum hsCRP ,TNF‐α ,MMP‐9 and plasma BNP ,and therapeutic effect were observed and compared between two groups before and after treatment .Results:Compared with routine treatment group after treatment ,there were significant reductions in onset times [ (5.67 ± 3.57) times／week vs .(2.81 ± 1. 18) times／week] and duration [ (4. 51 ± 1. 43) min／time vs.(1.37 ± 0. 87) min／time] of angina pectoris ,VAS score for pain degree [(5.69 ± 0.87) scores vs.(4. 08 ± 0.61 ) scores] ,levels of serum hsCRP [ (18.34 ± 4. 16 ) mg／L vs.(14.59 ± 3. 98 ) mg／L ] , TNF‐α [ (173. 41 ± 21.42) μg／L vs.(119. 03 ± 21. 83) μg／L] ,MMP‐9 [(368.51 ± 38. 24) μg／L vs.(303.77 ± 29. 97) μg／L] and plasma BNP [ (869.78 ± 82.89) pg／ml vs.(721. 36 ± 75.62) pg／ml] in metoprolol group , P＝0. 001 all. Conclusion:Metoprolol tartrate can improve therapeutic effect ,significantly improve angina and reduce serum levels of inflammatory factors in UAP patients .