MMP‐9 and P‐selectin in UAP patients / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of Tongxinluo capsule ,Shuxuetong injection combined carvedilol on ECG , serum levels of matrix metalloproteinase (MMP)‐9 and P‐selectin in patients with unstable angina pectoris (UAP). Methods:A total of 105 UAP patients were randomly divided into routine treatment group (n＝52) and combined treatment group (n＝53 ,received Tongxinluo capsule ,Shuxuetong injection and carvedilol based on routine treat‐ment group) ,both groups were continuously treated for one month .LVEF ,cardiac output (CO) ,serum levels of MMP‐9 and P‐selectin , therapeutic effects of ECG and angina pectoris , and incidence of adverse reactions were measured and compared between two groups before and after treatment .Results:Compared with routine treatment group , there were significant rise in total effective rates of ECG (59. 62% vs.79. 25%) and angina pectoris (71.15% vs.90.57%) in combined treatment group , P＜0. 05 both .Compared with routine treatment group after one‐month treatment ,there were significant rise in LVEF [ (45.30 ± 5.60 )% vs.(59. 33 ± 5. 31 )%] and CO [ (3.15 ± 1.14) L／min vs .(4. 92 ± 1. 18) L／min] ,and significant reductions in serum levels of P‐selectin [ (25. 40 ± 2.34) ng／ml vs.(16.85 ± 1. 62) ng／ml] and MMP‐9 [ (37. 30 ± 8. 91) μg／L vs.(27.80 ± 8.63) μg／L] in com‐bined treatment group , P＝0. 001 all.There was no significant difference in incidence of adverse reactions between two groups , P＝0.334. Conclusion:Tongxinluo capsule ,Shuxuetong injection combined carvedilol possess significant therapeutic effect on UAP patients .They can significantly improve cardiac function ,serum levels of P‐selectin and MMP‐9 with satisfying safety ,which is worth extending .