Effect of allergic factors on mycoplasma pneumoniae pneumonia in children / 中国医师进修杂志

ABSTRACT

Objective To analyze the clinical data of children with mycoplasma pneumoniae pneumonia (MPP), and investigate the effect of allergic factors on MPP in children and its mechanism. Methods Four hundred and ninety-one MPP patients were enrolled, 392 cases were enrolled in general MPP(GMPP) group, 99 cases in refratory MPP(RMPP) group, and 202 cases with non-MPP pneumonia (NMPP) were served as control group. Allergic diseases, mycoplasma peneumonia antibody (MP-Ab) titer, eosinophil (EOS) count and percentage of eosinophil (EOS%), basophil (BA) count were compared among the three groups. According to allergic diseases, two groups of patients were divided into allergic group (R-E group, G-E group) and non allergic group (R-NE group and G-NE group). MP-Ab titer, EOS/EOS%, BA count, lactic dehydrogenase (LDH) were compared among those groups. Results The occurrence of allergic diseases in RMPP group was significantly higher than that in RMPP group and NMPP group [41.4%(41/99) vs. 25.0% (98/392), 21.3% (43/202)](P<0.05 or<0.01) . The family history of allergic diseases in RMPP group was significantly higher than that in NMPP group [38.4% (38/99) vs. 23.3% (47/202)](P<0.01), but compared with that in GMPP group [29.8% (117/392)], there was no significant difference (P>0.05). MP-Ab titers of≥1∶1 280, 1∶(320-640) in RMPP group and GMPP group were statistically different(P < 0.01). EOS% in RMPP group was statistically different with other groups [(2.75 ± 2.67)% vs. (1.86 ± 1.90)%, (1.85 ± 1.92)%](P<0.05), EOS count in RMPP goup and GMPP group were statistically different [(0.20 ± 0.21)×109/L vs. (0.16 ± 0.16)×109/L] (P<0.01), but BA count showed no significant difference among the three groups (P>0.05). The MP-Ab titer, EOS/EOS%, BA count, LDH showed no significant differences between the allergic group and the non-allergic group (P>0.05). Conclusions MPP and RMPP in particular, has a similar immune mechanism to allergic diseases, and the allergic factors of children can make MP infection become more serious.