Studies on quality control of dexamethasone liposomes / 药学实践杂志
Journal of Pharmaceutical Practice
;
(6): 86-88, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-790301
ABSTRACT
OBJECTIVE:To study the main aspects of quality control of dexamethasone liposomes.METHODS:
The structure of liposomes was studied with negative staining method of TEM.K-ratio spectrophotometry was wsed to determine the contert,and the Macrosep was wsed to seperate the entrapped from free drugs.RESULTS:
An excellent linear relationship was obtained with the range of 4~52μg/ml,the average recovery percent was between 98.28%~99.71%.The entrapment efficiency was one of the important parameters of liposomes quality control.It was related with the clinical effect directly,the entrapment efficiency was more than 80%.CONCLUSION:
This method is accurate,quick and reproducible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Pharmaceutical Practice
Year:
2001
Type:
Article
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