A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter py lori eradication during clinical therapy / 药学实践杂志

ABSTRACT

Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy .Methods T rials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12 .0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment .Results Eight randomly controlled trials (n=114 4) were includ-ed .Pooled Hp eradication rates were 85.91% and 69 .21% for patients with and without Bifidobacterium viable triple capsule respectively ,with the odds ratio (OR) being 3 .07 (95% CI=2 .25~4 .19 ,test for overall effect Z= 7 .08 , P<0 .01);the occurrences of total adverse reactions were 7 .58% and 20.87% respectively ,with the summary OR being 0 .42 (95% CI=0 .29~0 .61 ,test for overall effect Z= 4 .48 , P< 0 .01) .The difference of the two groups was statistically significant . Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treat-ment and improve adverse reactions during therapy .