Interaction and active components of traditional Chinese medicine with clopi-dogrel on platelet aggregation / 药学实践杂志

ABSTRACT

Clopidogrel is commonly used as an anti-platelet aggregation drug in the clinical treatment ,which is often used in combination with traditional Chinese medicine .Strengthening the study on the interaction mechanism of Chinese herbal medicine and its active components with clopidogrel ,to improve the effect of anti-platelet aggregation and the therapeutic effect of clopidogrel resistance .The research progress on the interaction of Chinese herbal medicine and its active components with clopidogrel were summarized in domestic and foreign literatures .Cytochrome P450 ,liver carboxylesterase ,P glycoprotein is a major part of the interaction of traditional Chinese medicine and its active ingredient of clopidogrel .Some active components in Chinese medicine have synergistic effect of clopidogrel on platelet aggregation .