The evaluation and analysis on the results of voriconazole plasma concentration monitoring / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 421-423,446, 2016.
Article
in Zh
| WPRIM
| ID: wpr-790646
Responsible library:
WPRO
ABSTRACT
Objective To clarify the necessity of therapeutic drug monitoring (TDM ) of voriconazole ,and give relevant clinical tips ,by comparing the plasma concentration of different clinical specialties before and after adjustment of dose .Methods This is a retrospective study of voriconazole TDM data .It involves 435 cases voriconazole plasma trough concentration meas-urement results of 154 inpatients to make a preliminary assessment .Results 4 .3% plasma concentration were higher than 5 .5 μg/ml ,26 .5% plasma concentration were less than 1 .0 μg/ml in renal transplantation department ;while 52 .3% plasma concentration were higher than 5 .5 μg/ml ,no less than 1 .0 μg/ml in infectious disease department .Conclusions Therapeutic drug monitoring is necessary for rational use of voriconazole .The majority of plasma concentrations in renal transplantation pa-tients were <1 .0 μg/ml ,lower than recommended treatment concentration range ;while most infectious disease patients have> 5 .5 μg/ml ,higher than recommended treatment concentration range .Clinical pharmacists can be more closely involved in the clinical use of voriconazole based on the results of the therapeutic drug monitoring .
Full text:
1
Index:
WPRIM
Type of study:
Observational_studies
Language:
Zh
Journal:
Journal of Pharmaceutical Practice
Year:
2016
Type:
Article