Advances in the nanotechnology-based drug delivery systems of salinomycin / 药学实践杂志

ABSTRACT

Salinomycin ,extensively used as an antibiotic in animal husbandry for a long time ,has recently been found to possess strong anti-cancer and anti-cancer stem cell efficacy ,as well as activities to overcome multi-drug resistance of tumor based on studies in vivo and in vitro in case reports in pilot clinical trials .Therefore ,salinomycin promised to be a novel anti-cancer agent .However ,the unfavorable property of poor aqueous solubility and the adverse effects of salinomycin were greatly hinder its clinical use .In order to improve its therapeutic index and alleviate its toxicity ,studies on nanotechnology-based deliv-ery systems of salinomycin had been widely conducted .In this article ,the latest development and application of salinomycin nanoformulations were reviewed .