The application of dynastat in hepatic cancer patients after liver resection / 药学实践杂志

ABSTRACT

Objective To investigate the analgesia effects of dynastat in hepatic cancer patients after liver resection . Methods From June to December of year 2015 ,we collected 200 cases of hepatic cancer operation in the Eastern Hepatobiliary Surgery Hospital retrospectively .Those patients were divided into 2 groups (the dynastat treated group ,n=100 ;the untreated group ,n=100) .The patients in treated group were given dynastat 3 times (40 mg/5 ml ,iv ,6 hours ,18 hours and 30 hours af-ter operation respectively ) ,while the control group did not received any dynastat .The sufentanil analgesia pumps were used in both groups .The treated group received a lower sufentanil dose .The pain severity (VAS score) of patients and the postopera-tive untoward effects were compared between these two groups .The results were analyzed statistically .Results The VAS score and the postoperative untoward effects of the treated group were clearly lower than the control group .All differences have statistical significance(P<0 .05) Conclusions As a new-type selective COX-2 inhibitor for injection ,dynastat can reduce the dosage and side effects of opioid medicine .It deserves to be popularized in post operation analgesia .