Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy / 药学实践杂志

ABSTRACT

Objective To investigate the effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein regulation.Methods Patients were randomly divided into two groups.The control group received benazepine hydrochloride only.The experimental group received benazepine and spironolactone treatment.The blood pressure,renal function,24 h urinary protein,Cys-C,GFR,urinary microprotein and the correlation of GFR with Cys-C and urinary microprotein were recorded.Results There was no statistically significant difference between two groups in blood pressure(P>0.05).After treatment,the renal function of the experimental group was significantly improved compared to that of the control group.The 24 h urine protein,Cys-C and urinary microprotein were significantly lower in the experimental group than the control group(P<0.05).GFR was negatively correlated with Cys-C and urinary microprotein.Conclusion The com-bination therapy of ACEI and aldosterone receptor antagonist can improve renal function and reduce 24 h hematuria.GFR fil-tration ability was significantly improved with the reduction of Cys-C and urinary microprotein.