The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer′s disease / 药学实践杂志

ABSTRACT

Objective To evaluate the efficacy and safety of donepezil combined with memantine in the treatment of Alzheimer′s disease and provide a guidance for the proper clinical use of those medications.Methods The literatures published from 2014 to 2016 in CNKI/VIP/WanFang Med-online/CBM and other databases were collected.Screening and quality evalua-tion were carried out with include and exclude standard.The software RevMan 5.3 was used for data analysis.Results Eight-een studies included are randomized controlled trials with 900 cases in study group and 896 cases in control group.The com-bined results showed that MMSE,NPI and BEHAVE-AD of the combination therapy were superior to those of monotherapy group.There is no significant difference in ADL and ADAS-Cog.Conclusion The combination therapy was better than mono-therapy both in mental state and pathological behavior.The clinical application of those medications should be based on the spe-cific conditions of individual patient.