Study on the effects of different humidifying liquids applied to non-invasive mechanical ventilation airway humidification / 药学实践杂志

ABSTRACT

Objective To study the effects of different airway humidification fluid applied to non-invasive mechanical ventilation.Methods 121cases of non-invasive mechanical ventilation admitted to the hospital from May 2016to May 2017were randomly divided into three groups.40cases in group A received sterile water for injection as humidifying liquid.40cases in group B received normal saline and 41cases in group C received 1.25％sodium bicarbonate water solution.The viscosity of sputum and the comfort of humidification for the three groups were compared.Results On day 1, there was no significant difference in the sputum viscosity among the three groups. (F=0.230, P=0.795).On day 2, group A had the highest sputum viscosity, followed by group B and group C.The difference was statistically significant (F=4.416, P＜0.05).The same results were obtained on day 3with statistically significant difference (F=11.388, P＜0.001).Group C had the highest comfort score among the three groups with statistically significant difference (F=37.901, P＜0.001).Conclusion 1.25％sodium bicarbonate water solution makes sputum more diluted and gives patients with better comfort.It can be considered as the fluid of choice for patients with high sputum amount.