The relationship between insulin resistance and plasma hs-CRP in patients with chronic schizophrenia / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the relationship between insulin resistance and plasma hypersen-sitive reactive protein (hs-CRP) in patients with chronic schizophrenia. Methods A total of 247 inpatients with chronic schizophrenia ( patient group) and 166 cases of normal individuals( control group) were en-rolled. Their general demographic and clinical data were collected,fasting blood glucose,hs-CRP,c-peptide and insulin indexes were tested,and insulin resistance index (HOMA-IR) was calculated. The insulin resist-ance level of the patients group and the control group was compared by Mann-Whitney U test,and the rela-tionship between insulin-resistance and hs-CRP in patients group was analyzed using Spearman correlation a-nalysis. Results (1)The levels of C-peptide (2. 53(2. 06,3. 23)ng/ml vs 2. 24(1. 89,2. 87)ng/ml), in-sulin (7. 68(4. 66,11. 97)μIU/ml vs 7. 02(4. 31,9. 59) μIU/ml) and HOMA-IR (1. 75(1. 09, 3. 07) vs 1. 57(0. 97,2. 22)) in the patient group were significantly higher than those in the control group( all P<0. 05). ( 2) The levels of HOMA-IR( 1. 91( 1. 21,3. 74) vs 1. 70(1. 02,2. 72)) in patients with high hs-CRP(≥3 mg/L) was higher than those in the patients with low hs-CRP (<3 mg/L) (P<0. 05). ( 3) Spearman correlation analysis showed that HOMA-IR was positively correlated with plasma hs-CRP level in the patient group (r=0. 139,P<0. 05). (4)After logarithmic transformation of related variables,multivariate linear regression analysis showed that HOMA-IR was linearly correlated with hs-CRP level and boy weight in-dex. Conclusion The hs-CRP level in chronic schizophrenia has a positive predictive effect on insulin re-sistance. Detection of hs-CRP level in schizophrenic patients is helpful to assess metabolic risk of insulin.