Level of Vitamin D in patients with membranous nephropathy and the correlation with proteinuria / 中国综合临床

ABSTRACT

Objective To investigate the level of vitamin D in patients with membranous nephropathy and its correlation with proteinuria. Methods Eighty patients with membranous nephropathy were selected from May 2012 to May 2017 in the Department of Nephrology,Shijiazhuang First Hospital. They were divided into two groups with 40 cases in each group. The control group was given prednisolone acetate orally,while the study group was given prednisolone acetate and active vitamin D orally. All patients were followed up for 1 year. Blood urea nitrogen ( BUN), serum creatinine ( Scr), C-reactive protein ( CRP ), cholesterol (TC),triglyceride (TG),calcium (Ca),phosphorus (P),parathyroid hormone (PTH),urinary protein,1,25-dihydroxyvitamin D3 ( 1, 25 ( OH) 2D3) and transforming growth factor-beta ( TG) were measured monthly. F-beta 1 ) and other related biochemical indicators were recorded. Results Before treatment,the level of 1,25(OH) 2D3 in the control group was (3. 67+3. 67) μg／L,while that in the study group was (3. 69+3. 70) μg／L. There was no significant difference ( t＝1. 259,P＞0. 05) . One year after treatment,the level of 1,25(OH) 2D3 in the control group was (4. 87+2. 92) μg／L,while that in the study group was (19. 58+12. 12) μg／L,which was significantly higher in the study group than in the control group (t＝12. 384,P＜0. 05). Serum 1,25 (OH) 2D3 levels were positively correlated with blood calcium,plasma albumin,podocyte and TGF-β1 (r＝0. 301,0. 387,0. 342 and 0. 181,respectively,P＜0. 05); serum 1,25 ( OH) 2D3 levels were negatively correlated with blood phosphorus content,total cholesterol and 24 h urinary protein quantity (r value was －0. 265,－0. 033 and －0. 265,respectively,P＜0. 05) . Serum albumin was an independent factor of serum 1, 25 ( OH ) 2D3 ( P＜0. 05 ) . Conclusion The serum albumin is an independent risk factor for 1, 25 ( OH ) 2D3 in patients with membranous nephropathy. Vitamin D is negatively correlated with proteinuria. Active vitamin D has a better effect on proteinuria in patients with membranous nephropathy.