Analysis of the correlation between vitamin D deficiency and diabetic peripheral neuropathy / 中国综合临床

ABSTRACT

Objective To investigate the relationship between vitamin D deficiency and diabetic peripheral neuropathy (DPN) and the risk factors of DPN. Methods From April 2016 to may 2017,the clinical data of 62 patients with T2DM diagnosed and treated in Hebei Provincial Corps Hospital of armed police were analyzed retrospectively. Among them,31 patients with DPN ( DPN group), 31 patients with T2DM ( T2DM group),and 31 healthy subjects were selected as the control group. The basic data,blood lipid,blood glucose,liver and kidney function indexes,blood calcium,blood phosphorus,25 hydroxyvitamin d [25-(OH) D] level and vitamin D deficiency rate of the three groups were compared. The risk factors of DPN were analyzed by logistic regression model. Results The body mass index, waist-hip ratio, fasting blood glucose,insulin resistance index,glycosylated hemoglobin and blood calcium levels in T2DM group and DPN group were higher than those in healthy control group,and the body mass index,waist-hip ratio,course of diabetes mellitus and glycosylated hemoglobin levels in DPN group were higher than those in T2DM group, the differences were statistically significant (all P＜0. 05) . The serum concentration of 25 ( OH) d in DPN group and T2DM group was (11± 3) μg／L and ( 17± 3) μg／L,respectively,which were lower than that in healthy control group (29± 5) μg／L,and DPN group was lower than that in T2DM group. The difference between the three groups was statistically significant (F＝5. 969,P＜0. 001). The rate of vitamin D deficiency in DPN group and T2DM group was higher than that in healthy control group (54. 8%(17／31),35. 5%(11／31) vs. 19. 4%(6／31)),which was higher than that in T2DM group,the difference was statistically significant( χ2 ＝ 2. 207, P＜0. 05) . Multivariate logistic regression analysis showed that BMI, vitamin D deficiency and course of disease over 10 years were independent risk factors for diabetic peripheral neuropathy (OR＝3. 564,11. 023,4. 158,95% confidence interval 1. 923－6. 411,5. 988－26. 204,2. 619－6. 937,all P＜0. 001) . Conclusion Vitamin D deficiency is serious in DPN patients. BMI, vitamin D deficiency and course of disease over 10 years are independent risk factors for DPN.