Correlation studies of ultrasonic morphological types and the biological variation in calcification of the differentiated thyroid cancer / 中华超声影像学杂志

ABSTRACT

Objective To explore the correlation between ultrasound features and tumor biological variation with calcification morphological types in differentiated thyroid carcinoma ( DTC) . Methods T he clinical data of 598 patients with DTC calcification diagnosed by ultrasound ,surgery and clinicopathology were retrospectively analyzed . According to the 2017 edition of the American College of Radiology ( ACR) T hyroid Imaging Report and Data System ( T I‐RADS ) classification system standard ,DTC ultrasonic calcification morphological characteristics were divided into 5 types , and the correlation between DTC ultrasonic calcification morphological types and tumor biological characteristics and their variations were analyzed by Spearman correlation analysis . Results Of the 598 patients ,527 cases ( 88 .13% ) were typical papillary thyroid cancer( PTC) ,27 cases ( 4 .52% ) were typical follicular thyroid cancer( FTC) ,and 44 cases ( 7 .36% ) were variant subtype ( including 25 cases of follicular type ,9 cases of high cell type ,6 cases of clear cell type and 4 cases of eosinophilic type) . T I‐RADS diagnosis44 cases ( 7 .36% ) were Ⅰ ～ Ⅲ class , 179 cases ( 29 .93% ) were Ⅳ class performing fine needle aspiration cytology( FNAC) ,375 cases ( 62 .71% ) were Ⅴ class . T he coincidence rate between ultrasound and clinicopathological diagnosis was 92 .64% ( 554/598) . Morphological types of ultrasonic calcification in 554 cases of DTCtype Ⅰ microcalcification in 416 cases ( 75 .09% ) ;type Ⅱ calcification in 71 cases ( 12 .82% ) ;type Ⅲ calcification in 41 cases ( 7 .40% ) ;typeⅣ calcification in 20 cases ( 3 .61% ) ;type Ⅴ calcification in 6 cases ( 1 .08% ) . T here were correlations between type Ⅰ ,Ⅱ ,Ⅲ ultrasonic calcification morphological types and the tumor biological characteristics and its variant subtypes of DTC ( r ＝0 .634 ,0 .592 ,0 .479 ;all P ＝0 .01 ) . Conclusions T I‐RADS Ⅳ － Ⅴclass level+ Adler Ⅱ － Ⅲ blood flow has a high practical value for the ultrasonic diagnosis of DTC ,and FNAC can be performed in suspicious type Ⅳ DTC . Type Ⅰ － Ⅲ ultrasonic calcification morphological types and the main types of tumor biological characteristics and its variant of DTC ,and has an important clinical value for the diagnosis of DTC by ultrasound ,which provides an important reference basis for guiding FNAC ,selecting surgical procedure ,postoperative follow‐up and prognosis judgment .