The progress of interleukin-33 on liver diseases / 中华肝胆外科杂志

ABSTRACT

Interleukin-33 (IL-33) is a multifunctional gene in the interleukin-1 family and is widely expressed in human tissues.Its receptor is ST2,is associated with asthma,diabetes,Alzheimer's disease,cardiovascular disease,inflammatory bowel disease,and cancer.IL-33,enhancing lipid metabolism and down-regulating adipogenic gene expression by inducing Th2 cytokine production,plays a protective role in fatty liver.In hepatitis,the IL-33/NKT/IFN-γ pathway exacerbates mouse hepatitis.While,the IL-33/ILC2/IL-13/STAT6 pathway reduces liver damage.The IL-33/ILC2/IL-13/IL-4Rα/STAT6 axis plays a facilitating role in cirrhosis.In liver cancer,IL-33/ILC2/IL-13 signaling pathway is found to promote cholangiocarcinoma in a favorable pathological environment,and hepatocellular carcinoma occurs by IL-33/IL-6/JAK/STAT/Mcl-1 signaling pathway.