Expression of GP73 in liver cirrhosis and its assistant value in grading of liver cirrhosis / 中华核医学与分子影像杂志

ABSTRACT

Objective To investigate the expression of Golgi protein 73 ( GP73) in liver cirrhosis and its assistant value in grading of liver cirrhosis. Methods A total of 160 patients with liver cirrhosis (96 males, 64 females, age(58.6±10.3) years) and 60 healthy controls (35 males, 25 females, age (53.5± 12.2) years) were included to detect the GP73 level. Serum levels of alpha-fetoprotein (AFP), albumin ( ALB) , total bilirubin ( TBIL) and prothrombin time ( PT) were also measured. The correlations between the above indicators and the GP73 level were analyzed with Pearson correlation. The GP73 levels among pa-tients with different Child-Pugh grading and different CT morphological grading were compared using one-way analysis of variance and the least significant difference t test. The receiver operating characteristic ( ROC) curve analysis was used to analyze the diagnostic sensitivity and specificity of GP73/AFP for liver cirrhosis. Results The area under the ROC curve for GP73 was 0.886 with the cut-off value of 144.5μg/L. The sensitivity of GP73 in the diagnosis of liver cirrhosis was 70.4％, and the specificity was 87.8％. After combining with AFP, the sensitivity and specificity were elevated to 71.6％ and 90.2％ respectively. GP73 levels among patients with different Child-Pugh grading and those with different CT morphological grading were significantly different ( F3.15, 2.82, both P<0.05) , and GP73 levels among groups also showed sig-nificant differences (all P<0.05). The GP73 level was correlated with AFP, ALB, TBIL, and PT (r val-ues0.362, -0.428, 0.672, 0.575, all P<0.01) . Conclusion Serum GP73 level increases with progres-sion of liver cirrhosis, and it has an assistant value in the diagnosis of liver cirrhosis.