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Expression of GP73 in liver cirrhosis and its assistant value in grading of liver cirrhosis / 中华核医学与分子影像杂志
Chinese Journal of Nuclear Medicine and Molecular Imaging ; (6): 597-600, 2019.
Article in Chinese | WPRIM | ID: wpr-791567
ABSTRACT
Objective To investigate the expression of Golgi protein 73 ( GP73) in liver cirrhosis and its assistant value in grading of liver cirrhosis. Methods A total of 160 patients with liver cirrhosis (96 males, 64 females, age(58.6±10.3) years) and 60 healthy controls (35 males, 25 females, age (53.5± 12.2) years) were included to detect the GP73 level. Serum levels of alpha-fetoprotein (AFP), albumin ( ALB) , total bilirubin ( TBIL) and prothrombin time ( PT) were also measured. The correlations between the above indicators and the GP73 level were analyzed with Pearson correlation. The GP73 levels among pa-tients with different Child-Pugh grading and different CT morphological grading were compared using one-way analysis of variance and the least significant difference t test. The receiver operating characteristic ( ROC) curve analysis was used to analyze the diagnostic sensitivity and specificity of GP73/AFP for liver cirrhosis. Results The area under the ROC curve for GP73 was 0.886 with the cut-off value of 144.5μg/L. The sensitivity of GP73 in the diagnosis of liver cirrhosis was 70.4%, and the specificity was 87.8%. After combining with AFP, the sensitivity and specificity were elevated to 71.6% and 90.2% respectively. GP73 levels among patients with different Child-Pugh grading and those with different CT morphological grading were significantly different ( F3.15, 2.82, both P<0.05) , and GP73 levels among groups also showed sig-nificant differences (all P<0.05). The GP73 level was correlated with AFP, ALB, TBIL, and PT (r val-ues0.362, -0.428, 0.672, 0.575, all P<0.01) . Conclusion Serum GP73 level increases with progres-sion of liver cirrhosis, and it has an assistant value in the diagnosis of liver cirrhosis.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Nuclear Medicine and Molecular Imaging Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Nuclear Medicine and Molecular Imaging Year: 2019 Type: Article