Application of nanomaterials in enhancing internal radiotherapy of radionuclide for cancer / 中华核医学与分子影像杂志

ABSTRACT

The therapeutic efficiency of radionuclides for cancer is closely related to the accumula-tion level, residence time and distribution in tumor, and is also influenced by the radiation resistance and hypoxia microenvironment of tumor. Nanomaterials, with a series of characteristics including special dimen-sion effect and functionally modifiable surface, can not only work as the isotopic carrier to transport nuclide into tumor, but also combine with chemical, thermal or photodynamic therapies to generate synergistic thera-peutic effect or destroy the hypoxic microenvironment of tumor to reduce radiation resistance, thus achieving the radiosensitization effect. This article reviews the application of nanomaterials in enhancing the therapeu-tic efficiency of radionuclide for cancer.