Predictors of Avascular Necrosis after Kidney Transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 200-206, 2017.
Article
in English
| WPRIM
| ID: wpr-79169
ABSTRACT
BACKGROUND:
Risk factors for bone avascular necrosis (AVN), a common late complication after kidney transplantation (KT), are not well known.METHODS:
Patients that underwent living-donor KT at Asan Medical Center between January 2009 and July 2016 were included in this retrospective study to determine the incidence and risk factors for AVN after KT.RESULTS:
Among 1,570 patients that underwent living-donor KT, 33 (2.1%) developed AVN during a mean follow-up of 49.8±25.0months. Additionally, AVN was diagnosed at a mean of 13.9±6.6 months after KT. The mean cumulative corticosteroid dose during the last follow-up in patients without AVN (9,108±3,400 mg) was higher than that that in patients with AVN (4,483±1,114 mg) until AVN development (P < 0.01). More patients among those with AVN (n=4, 12.1%) underwent steroid pulse treatment because of biopsy-proven rejections during the first 6 months after KT than patients without AVN (n=68, 4.4%; P=0.04). Female (hazard ratio [HR], 2.29; P=0.04) and steroid pulse treatment during the first 6 months (HR, 2.31; P=0.02) were significant AVN risk factors as revealed by the Cox proportional multivariate analysis. However, no significant differences in rejection-free graft survival rates were observed between the two groups (P=0.67).CONCLUSIONS:
Steroid pulse treatment within 6 months of KT and being female were independent risk factors for AVN development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteonecrosis
/
Incidence
/
Multivariate Analysis
/
Retrospective Studies
/
Risk Factors
/
Follow-Up Studies
/
Immunosuppression Therapy
/
Kidney Transplantation
/
Graft Survival
/
Kidney
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
The Journal of the Korean Society for Transplantation
Year:
2017
Type:
Article
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