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A Case of Chronic Myeloid Leukemia with Multiple Chloromas Treated Successfully with Dasatinib / 계명의대학술지
Keimyung Medical Journal ; : 120-126, 2015.
Article in English | WPRIM | ID: wpr-79179
ABSTRACT
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the primitive hematopoietic stem cells. CML is characterized by the overproduction of myeloid cells, which results in marked splenomegaly and leukocytosis. CML presented by multiple chloromas is extremely rare. Multiple chloromas in the skin and brain are quite rare as the initial presentation of CML. These rare manifestation should alert clinicians to include CML in the differential diagnosis of patients presenting with multiple non-pruritic skin nodules or neurologic symptoms. Dasatinib has promising therapeutic potential for managing intracranial leukemic disease. Here, we report the case of a patient who visited the hospital with multiple chloroma which is unusual presentation of CML, and treated with dasatinib successfully.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Splenomegaly / Brain / Hematopoietic Stem Cells / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Myeloid Cells / Sarcoma, Myeloid / Diagnosis, Differential / Dasatinib / Leukocytosis Type of study: Diagnostic study Limits: Humans Language: English Journal: Keimyung Medical Journal Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Splenomegaly / Brain / Hematopoietic Stem Cells / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Myeloid Cells / Sarcoma, Myeloid / Diagnosis, Differential / Dasatinib / Leukocytosis Type of study: Diagnostic study Limits: Humans Language: English Journal: Keimyung Medical Journal Year: 2015 Type: Article