Correlation between preoperative controlling nutritional status (CONUT) score and adjuvant chemotherapy in stage Ⅱ-Ⅲ gastric cancer after curative resection / 中华普通外科杂志

ABSTRACT

Objectives To elucidate the prognostic impact of preoperative control of nutritional status (CONUT) scores on gastric cancer patients undergoing adjuvant chemotherapy after radical gastrectomy.Methods A retrospective analysis of 536 stage Ⅱ-Ⅲ gastric cancer patients undergoing adjuvant chemotherapy after radical resection from Jul 1998 to Dec 2014 was performed.Patients were divided into high (≥ 3) and low (≤ 2) CONUT groups with a CONUT score of 3 divided into critical values.Results The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (37.3 ％ vs.55.7％,P ＜0.001).Univariate analysis showed that the high CONUT group was associated with larger tumors,more lymph node metastasis,lower body mass index,higher prognostic nutritional index,and preoperative anemia (all P ＜ 0.05).Multivariate analysis showed that the CONUT score was an independent prognostic factor for patients with gastric cancer (HR1.564,95％ CI1.090-2.321,P =0.016).The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (P ＜ 0.05).Conclusion The CONUT score is an indicator for predicting the prognosis of patients with stage Ⅱ-Ⅲ gastric cancer after adjuvant chemotherapy.The nutritional evaluation is helpful to develop a plan for preoperative nutritional intervention.