Underlying Hemato-oncologic, Gastrointestinal-nutritional Diseases, or Prematurity May Be Risk Factors for Hypovitaminosi D in Children / 계명의대학술지
Keimyung Medical Journal
;
: 89-97, 2015.
Article
in English
| WPRIM
| ID: wpr-79183
ABSTRACT
PURPOSE:
An adequate vitamin D level is important for normal growth, cancer prevention, controlling hormones, and immune regulation. However, no study has investigated vitamin D status in patients with serious illnesses, such as malignancies, malabsorption diseases, or prematurity in Korean children. Thus, we analyzed the results of 25-hydroxyvitamin D3 (25-D) levels in children in a single tertiary medical center.METHODS:
Children who had their vitamin D level evaluated at Keimyung University Dongsan Medical Center from January 2004 to December 2014 were included. We reviewed the medical records and laboratory test results.RESULTS:
Ninety-three children (malefemale = 4845) who had their vitamin D levels measured were included. The most common reason for measuring vitamin D level was hypocalcemia with or without neurological signs. Among the subjects, 61 children had hypovitaminosis D (25-D < 30 ng/mL). A positive correlation was detected between 25-D and total calcium levels (p = 0.001). Negative correlations were found between 25-D and immunoreactive parathyroid hormone (iPTH) levels (p = 0.002) and between 25-D and alkaline phosphatase (ALP) levels (p = 0.021). Twenty-three subjects (37.7%) had a critical underlying condition, including a hemato-oncologic issue (18.0%), gastrointestinal or nutritional problem (11.5%), and prematurity or low birth weight (8.2%).CONCLUSION:
The levels of total calcium, ALP, and iPTH were correlated with 25-D level. An underlying malignancy, malabsorption issues, or prematurity may be risk factors for hypovitaminosis D in children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parathyroid Hormone
/
Vitamin D
/
Calcifediol
/
Infant, Low Birth Weight
/
Medical Records
/
Calcium
/
Risk Factors
/
Alkaline Phosphatase
/
Hypocalcemia
Type of study:
Etiology study
/
Risk factors
Limits:
Child
/
Humans
/
Infant, Newborn
Language:
English
Journal:
Keimyung Medical Journal
Year:
2015
Type:
Article
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