Correlation between type 2 diabetes mellitus and hepatocellular carcinoma:a case-control study / 中华消化杂志

ABSTRACT

Objective To investigate the correlation between type 2 diabetes mellitus (T2DM)and hepatocellular carcinoma (HCC)by case-control study. Methods From January 2006 to December 2015,the data of 1350 first diagnosis HCC patients at the First Affiliated Hospital of Zhengzhou University were collected and analyzed. The univariate and multivariate logistic regression were performed to analyze the risk factors of HCC genesis,and the risk factors were further stratified. Results The results of univariate logistic regression analysis showed that smoking and obesity were not risk factors of HCC genesis (both P > 0. 05). Alcoholism, hepatitis B virus (HBV)infection,hepatitis C virus (HCV)infection,T2DM,and family history of HCC were the risk factors of HCC genesis (odds ratio (OR)= 2. 593,4. 583,3. 732,1. 955 and 1. 622,95％ confidence interval (CI)1. 883 to 3. 549,3. 026 to 6. 940,2. 544 to 5. 367,1. 708 to 2. 477 and 1. 314 to 2. 267,all P < 0. 05). The results of multivariate logistic regression analysis indicated that alcoholism,HBV infection, HCV infection,T2DM and family history of HCC were independent risk factors of HCC genesis (OR = 2. 034, 4. 564,2. 831,1. 881 and 1. 616,95％ CI 1. 507 to 2. 745,2. 672 to 7. 765,1. 562 to 5. 047,1. 314 to 2. 671 and 1. 177 to 2. 228,all P < 0. 01),and T2DM could increase the risk of HCC genesis (P < 0. 01). In order to exclude the interference of alcoholism,HBV infection and HCV infection on above results,further stratified analysis showed that T2DM was one of the independent risk factors of HCC genesis (χ2 = 5. 190,P = 0. 023), and had synergistic effect with alcoholism,HBV infection and HCV infection (χ2 = 32. 848,P < 0. 01). There were significant differences in the propovtion,duration of disease and hemoglobin A 1c level of T2DM patients between the case group and the control group (χ2 = 46. 618,81. 644 and 43. 092,all P < 0. 01). Conclusions T2DM is one of the independent risk factors or HCC genesis. T2DM is correlated with the pathogenesis of HCC. The clinical desease course and blood glucose control in patients with T2DM are also correlated with the pathogenesis of HCC.