Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia / 소아과
Korean Journal of Pediatrics
;
: 527-531, 2004.
Article
in Korean
| WPRIM
| ID: wpr-7923
ABSTRACT
PURPOSE:
This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia.METHODS:
Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and their newborns(normotensive group) were observed. IGF-I and 1,25-(OH)2 Vit. D3 concentrations in maternal and umbilical cord blood were analysed.RESULTS:
Maternal and umbilical cord blood levels of IGF-I and 1,25-(OH)2 Vit. D3 were significantly lower in the preeclampsia group than in the normotensive group. In the preeclampsia group, maternal and cord blood levels of IGF-I of small-for-gestational age newborns were significantly lower than those of appropriate-for-gestational age newborns. The birth weight and length of newborns correlated with IGF-I concentrations of maternal and umbilical cord blood in small-for-gestational age newborns of preeclampsia group. The correlation between IGF-I and 1,25-(OH)2 Vit. D3 was significant in the umbilical cord blood of preeclampsia group, but only in appropriate-for-gestational age newborns.CONCLUSION:
It is suggested that the lower level of IGF-I is the primary factor of intrauterine growth retardation in preeclampsia, and the effect of IGF-I on the metabolism of 1,25-(OH)2 Vit. D3 is different according to the presence of preeclampsia and intrauterine fetal growth retardation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pre-Eclampsia
/
Vitamins
/
Birth Weight
/
Insulin-Like Growth Factor I
/
Cholecalciferol
/
Pregnant Women
/
Fetal Development
/
Fetal Blood
/
Fetal Growth Retardation
/
Metabolism
Limits:
Female
/
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS