The expression of Twist and E -cadherin and its clinical significance in ovarian endometriosis / 预防医学

ABSTRACT

Objective To know the expression and clinical significance of Twist1,Twist2 and E -cadherin in ovarian endometrium.Methods Immunohistochemistry was used to detect the expression of Twist1,Twist2 and E -cadherin in tissues of ovarian endometrium (EMs I -II,n =24;EMs III -IV,n =30)andnormal endometriums without endometriosis (Control,n =24).Results The expression levels of Twist1,Twist2 were significantly higher in EMs I -II (4.25 ±0.79, 3.83 ±0.96 respectively)and EMs III -IV (4.67 ±0.88,4.30 ±0.95 respectively)while the values of the control group were 3.50 ±0.83,3.54 ±0.88 respectively(both P <0.05),and the group of EMs III -IV had a higher expression of Twist2 (4.30 ±0.95)than that in EMs I -II (3.83 ±0.96)(P <0.05 ).At the same time,the expression of E -cadherin were significantly lower in EMs I -II (3.79 ±0.98)and EMs III -IV (3.57 ±0.73)than the control (4.54 ± 0.93)(P <0.05).The expression of Twist1 and Twist2 was negatively related to that of E -cadherin respectively (both P<0.05),while the expression of Twist1 was positively related to that of Twist2 (P <0.05).Conclusion Twist1,Twist2 and E -cadherin are closely related to the prevalence of endometriosis,while the ability of invasion and metastasis may be associated with the high expression of Twist1 and Twist2,as well as the low expression of E -cadherin.