Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 2156-2161, 2003.
Article
in Korean
| WPRIM
| ID: wpr-79243
ABSTRACT
Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance. To date, the TRAIL (TNF-related apoptosis-inducing ligand) system is known to be another pivotal mechanism. OBJECTIVE:
To clarify the protein expression of TRAIL ligand and receptors in the normal and pathologic (preeclampsia, hydatidiform mole) placenta, chorioamnion, decidua.METHODS:
we investigated the expression of TRAIL system in the above-mentioned tissues by using Western Hybridization.RESULTS:
All tissues expressed TRAIL ligand and only a DcR2 among TRAIL receptors (DR4, DR5, DcR1, DcR2).CONCLUSION:
we demonstrated the expression of TRAIL ligand and DcR2 protein at the feto-maternal interface of the normal and pathologic pregnancies. Further study regarding the expression of other receptors and quantitative analysis between normal and pathologic pregnancies should be followed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Uterus
/
Apoptosis
/
Decidua
/
Gestational Trophoblastic Disease
/
Receptors, TNF-Related Apoptosis-Inducing Ligand
/
Fertilization
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS