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Effect of 5alpha-Reductase Inhibitor in Expression of Transforming Growth Factor-beta1 in Benign Prostatic Hyperplasia Patients / 대한비뇨기과학회지
Korean Journal of Urology ; : 1178-1184, 2006.
Article in Korean | WPRIM | ID: wpr-79263
ABSTRACT

Purpose:

Transforming growth factor (TGF)-beta is a member of the superfamily of polypeptides, which control cell cycle progression and a variety of other cellular activities. TGF-beta1 has been implicated as an effector of the induction of apoptosis in response to 5alpha-reductase inhibitor (5ARI) and; therefore, causes a decrease in the prostate volume. We investigated the effect of 5ARI in the expression of TGF-beta1 in benign prostatic hyperplasia (BPH). Materials and

Methods:

50 patients diagnosed with BPH were divided into two groups. The control group (n=30), in which a transurethral resection of the prostate (TURP) was performed without medication, and the 5ARI group (n=20), who were administrated with 5 mg of 5ARI daily for at least 3 months, followed by TURP. The resected specimens were stained with anti-rabbit TGF-beta1 polyclonal antibody using immunofluoroscent staining. The expression of TGF-beta1 was analyzed with a confocal laser scanning microscope and an image analyzer. The mRNA level of TGF-beta1 was determined by reverse transcriptase-polymerase chain reaction (RT-PCR).

Results:

There were no statistical differences in the patient characteristics, including age, serum prostate-specific antigen (PSA) level and prostate volume, between the two groups. The expression of TGF-beta1 was demonstrated in the luminal epithelium and smooth muscle cells in BPH. TGF-beta1 was more strongly expressed in the luminal epithelium of both groups, and in the 5ARI group than the control (p<0.001).

Conclusions:

These results suggest that 5ARI up-regulates the expression of TGF-beta1 in BPH patients, and may a play role as an inhibitor in the proliferation of BPH through the TGF-beta1 signal pathway.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides / Phenobarbital / Prostate / Prostatic Hyperplasia / RNA, Messenger / Signal Transduction / Transforming Growth Factors / Cell Cycle / Prostate-Specific Antigen / Apoptosis Limits: Humans Language: Korean Journal: Korean Journal of Urology Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides / Phenobarbital / Prostate / Prostatic Hyperplasia / RNA, Messenger / Signal Transduction / Transforming Growth Factors / Cell Cycle / Prostate-Specific Antigen / Apoptosis Limits: Humans Language: Korean Journal: Korean Journal of Urology Year: 2006 Type: Article