Triptolide inhibits activity of human cervical microvascular endothelial cells / 中国肿瘤生物治疗杂志
Chinese Journal of Cancer Biotherapy
;
(6): 196-199, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-793100
ABSTRACT
@#Objective:
To investigate the inhibitory effect of Triptolide on vasculogenesis of human cervical microvascular endothelial cells, and to explore the mechanism.Methods:
Human cervical microvascular endothelial cells (HCerMECs) were used as research subject, and treated with different concentrations of Triptolide (0, 5, 10, 20 and 40 ng/ml) i n v i t r o . The effect of Triptolide on cell proliferation was determined by CCK-8, the cell migration ability was detected by Transwell assay while the expression of vascular endothelial growth factor (VEGF) was examined by western blotting.Results:
Triptolide inhibited the proliferation and migration of HCerMECs in a dose-dependent manner ( P <0.05). In addition, Triptolide could inhibit the expression of VEGF in HCerMECs in a concentration-dependent manner.Conclusions:
Triptolide could inhibit the proliferation and migration activity of HCerMECs which is related with the suppression of VEGF expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Cancer Biotherapy
Year:
2019
Type:
Article
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