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Inhibitory effects of interleukin-10 plasmid DNA on the development of atopic dermatitis-like skin lesions in NC/Nga mice
Journal of Veterinary Science ; : 213-220, 2010.
Article in English | WPRIM | ID: wpr-79617
ABSTRACT
Interleukin (IL)-10 exerts potent anti-inflammatory effects by suppression of both T-help (Th) 1 and Th2 cells. Previous studies have reported that IL-10 can ameliorate various inflammatory disorders. The present study was performed to examine whether IL-10 plasmid DNA could suppress development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice, as an initial step towards the development of an appliance for use in dogs with AD. Intradermal injection of IL-10 plasmid DNA markedly inhibited the development of AD-like skin lesions, as evidenced by a marked decrease in skin symptoms and reduced inflammation within the skin lesions. Efficacy was confirmed by significant decreases in eosinophil ratio and serum IgE concentration, and a reduction in the number of Staphylococcus aureus recovered from the ear. Moreover, relative mRNA expression levels of IL-4 and interferon-gamma in the skin lesions of mice injected with IL-10 plasmid DNA were also decreased compared with those of control mice. Of note, higher serum IL-10 levels in mice injected with IL-10 plasmid DNA were maintained compared with those in control mice. Taken together, the results indicate that IL-10 plasmid DNA can suppress the development of AD-like skin lesions by suppressing both Th1 and Th2 cell responses. Beneficial effects of IL-10 plasmid DNA may be expected in dogs with AD.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmids / Staphylococcus aureus / Case-Control Studies / Interleukin-10 / T-Lymphocytes, Helper-Inducer / DNA Primers / Statistics, Nonparametric / Dermatitis, Atopic / Disease Models, Animal / Mice, Mutant Strains Type of study: Observational study / Prognostic study Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmids / Staphylococcus aureus / Case-Control Studies / Interleukin-10 / T-Lymphocytes, Helper-Inducer / DNA Primers / Statistics, Nonparametric / Dermatitis, Atopic / Disease Models, Animal / Mice, Mutant Strains Type of study: Observational study / Prognostic study Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2010 Type: Article