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Resuscitation incoherence and dynamic circulation-perfusion coupling in circulatory shock / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1218-1227, 2019.
Article in English | WPRIM | ID: wpr-796453
ABSTRACT

Objective:

@#Poor tissue perfusion/cellular hypoxia may persist despite restoration of the macrocirculation (Macro). This article reviewed the literatures of coherence between hemodynamics and tissue perfusion in circulatory shock.@*Data sources@#We retrieved information from the PubMed database up to January 2018 using various search terms or/and their combinations, including resuscitation, circulatory shock, septic shock, tissue perfusion, hemodynamic coherence, and microcirculation (Micro).@*Study selection@#The data from peer-reviewed journals printed in English on the relationships of tissue perfusion, shock, and resuscitation were included.@*

Results:

@#A binary (coherence/incoherence, coupled/uncoupled, or associated/disassociated) mode is used to describe resuscitation coherence. The phenomenon of resuscitation incoherence (RI) has gained great attention. However, the RI concept requires a more practical, systematic, and comprehensive framework for use in clinical practice. Moreover, we introduce a conceptual framework of RI to evaluate the interrelationship of the Macro, Micro, and cell. The RI is divided into four types (Type 1 Macro-Micro incoherence + impaired cell; Type 2 Macro-Micro incoherence + normal cell; Type 3 Micro-Cell incoherence + normal Micro; and Type 4 both Macro-Micro and Micro-cell incoherence). Furthermore, we propose the concept of dynamic circulation-perfusion coupling to evaluate the relationship of circulation and tissue perfusion during circulatory shock.@*

Conclusions:

@#The concept of RI and dynamic circulation-perfusion coupling should be considered in the management of circulatory shock. Moreover, these concepts require further studies in clinical practice.

Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Chinese Medical Journal Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Chinese Medical Journal Year: 2019 Type: Article