Effect of allergic factors on mycoplasma pneumoniae pneumonia in children / 中国医师进修杂志

ABSTRACT

Objective@#To analyze the clinical data of children with mycoplasma pneumoniae pneumonia (MPP), and investigate the effect of allergic factors on MPP in children and its mechanism.@*Methods@#Four hundred and ninety-one MPP patients were enrolled, 392 cases were enrolled in general MPP(GMPP) group, 99 cases in refratory MPP(RMPP) group, and 202 cases with non-MPP pneumonia (NMPP) were served as control group. Allergic diseases, mycoplasma peneumonia antibody (MP-Ab) titer, eosinophil (EOS) count and percentage of eosinophil (EOS%), basophil (BA) count were compared among the three groups. According to allergic diseases, two groups of patients were divided into allergic group (R-E group, G-E group) and non allergic group (R-NE group and G-NE group). MP-Ab titer, EOS/EOS%, BA count, lactic dehydrogenase (LDH) were compared among those groups.@*Results@#The occurrence of allergic diseases in RMPP group was significantly higher than that in RMPP group and NMPP group [41.4%(41/99) vs. 25.0% (98/392), 21.3% (43/202)](P < 0.05 or < 0.01). The family history of allergic diseases in RMPP group was significantly higher than that in NMPP group [38.4% (38/99) vs. 23.3% (47/202)](P < 0.01), but compared with that in GMPP group [29.8% (117/392)], there was no significant difference (P > 0.05). MP-Ab titers of ≥ 1∶1 280, 1∶(320-640) in RMPP group and GMPP group were statistically different(P < 0.01). EOS% in RMPP group was statistically different with other groups [(2.75 ± 2.67)% vs. (1.86 ± 1.90)%, (1.85 ± 1.92)%](P < 0.05), EOS count in RMPP goup and GMPP group were statistically different [(0.20 ± 0.21) ×109/L vs. (0.16 ± 0.16) ×109/L] (P < 0.01), but BA count showed no significant difference among the three groups (P > 0.05). The MP-Ab titer, EOS/EOS%, BA count, LDH showed no significant differences between the allergic group and the non-allergic group (P > 0.05).@*Conclusions@#MPP and RMPP in particular, has a similar immune mechanism to allergic diseases, and the allergic factors of children can make MP infection become more serious.