The Concept and Overview of Spondyloarthritis / 대한내과학회지
Korean Journal of Medicine
;
: 229-239, 2013.
Article
in Korean
| WPRIM
| ID: wpr-79712
ABSTRACT
The spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic diseases in association with HLA-B27. They share the clinical features including sacroiliitis, spondylitis, oligoarthritis, enthesitis and extra-articular involvement. Recently ASAS proposed new classification criteria sets of axial and peripheral SpA. They were designed to include non-radiographic SpA, thus can guide the early diagnosis of disease before the structural damage occurs. SpA has a strong genetic predisposition. Non-MHC genes, such as IL23R and ERAP1, as well as HLA-B27 were confirmed as susceptibility genes through several GWAS. Major pathology in SpA is entheseal inflammation and new bone formation. Intrinsic ability of HLA-B27 to trigger innate immune response and several proinflammtory cytokines may contribute to the inflammation in SpA. New bone formation could be explained by a mechanism, partly or completely independent of the inflammatory process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Spondylitis
/
Spondylitis, Ankylosing
/
HLA-B27 Antigen
/
Rheumatic Diseases
/
Cytokines
/
Genetic Predisposition to Disease
/
Early Diagnosis
/
Sacroiliitis
/
Immunity, Innate
Type of study:
Diagnostic study
/
Screening study
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2013
Type:
Article
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