Related factors for early neurological improvement after intravenous thrombolysis with alteplase in elderly patients with acute ischemic stroke / 中华老年医学杂志

ABSTRACT

Objective@#To analyze related factors for early neurological improvement after intravenous thrombolysis with alteplase in elderly patients with acute ischemic stroke(AIS).@*Methods@#Clinical data of elderly AIS patients with intravenous thrombolytic therapy within 4.5 hours of symptom onset were retrospectively analyzed.The demographic and clonical data were compared between improvement group and non-improvement group.Relevant factors for early neurological improvement after thrombolysis with alteplase were analyzed by using multivariate logistic regression model.@*Results@#A total of 118 patients were included, of which 43 had early symptom improvement(36.44%). Multivariate logistic regression analysis showed that baseline NIHSS score(OR=1.098, 95%CI=1.002-1.202, P=0.045), admission blood glucose(OR=1.377, 95%CI=1.040-1.822, P=0.025), atrial fibrillation(OR=0.329, 95%CI=0.122-0.883, P=0.027)were significantly correlated with early symptom improvement after thrombolysis.@*Conclusions@#Baseline NIHSS score, admission blood glucose and atrial fibrillation are correlated with early neurological improvement after intravenous thrombolysis with alteptase in elderly AIS patients.