Association analysis of testosterone, dehydroepiandrosterone and cholelithiasis in transitional menopausal women / 中华肝胆外科杂志

ABSTRACT

Objective@#To investigate the relationship between testosterone, dehydroepiandrosterone (DEHA) and cholelithiasis among women in climacteric transition period.@*Methods@#A total of 2 127 women aged 40~55 were included from the Study of Women's Health Across the Nation. Individuals were divided into gallstone group (n=129) and control group (n=1 998). Serum testosterone, DEHA and other clinical indicators were measured. Mann-Whitney U test was used to compare the averages of continuous variables between groups. Logistic regression was used to analyse the associations between testosterone and DEHA and cholelithiasis.@*Results@#The gallstone group had higher testosterone, systolic blood pressure, BMI, waist circumference, hip circumference, triglyceride, C-reactive protein, and lower DHEA, sex hormone binding globulin and high density lipoprotein (P<0.05). After fully adjusting the covariates, testosterone and DEHA levels were correlated with gallstone occurrence, OR (95% CI) were 1.010(1.005~1.015) and 0.994 (0.991~0.997), respectively. In multivariate logistic regression, testosterone may be independent risk factors for gallstones, OR (95% CI) were 1.012(1.007~1.016). DEHA may be independent protective factors for the end of gallbladder, OR (95%CI) were 0.994 (0.991~0.997).@*Conclusion@#Testosterone was positively correlated with gallstone risk and DEHA was negatively correlated with gallstone risk in transitional menopausal women.