Effect of nabuprofen and sufentanil on analgesia score and sedation score in patients with total hip arthroplasty / 中国基层医药

ABSTRACT

Objective@#To analyze the effects of nabuprofen combined with sufentanil on Ramsay sedation score, visual analogue scale (VAS) and analgesic effect in patients undergoing total hip arthroplasty (THA) for patient-controlled intravenous analgesia (PCIA).@*Methods@#From January 2017 to December 2017, 72 patients with THA in the Department of Orthopedics from the People's Hospital of Linfen were divided into three groups A group was given nabuprofen, B group was given sufentanil, C group was given nabuprofen + sufentanil, with 24 cases in each group.Ramsay sedation score, VAS score and analgesic effect were compared among the three groups before and after operation.@*Results@#The Ramsay sedation scores of A group at 3, 12 and 24 hours after operation were (2.78±0.32)points, (2.59±0.40)points and (2.4±0.26)points, respectively, and the Ramsay sedation scores of C group at 3, 12 and 24 hours after operation were (2.37±0.24)points, (2.0±0.15)points, (1.89±0.22)points, respectively, which were decreased significantly compared with those of B group at the same time point [(3.07±0.58)points, (3.01±0.62)points and (2.73±0.47)points] (Fbetween group=6.83, Pbetween group=0.01; Ftime point=7.24, Ptime point<0.01; Fbetween group·time point=0.69, Pbetween group·time point=0.40). The VAS scores of group B at 3, 12 and 24 hours after operation were (2.40±0.72)points, (1.98±0.57)points and (1.24±0.38)points, respectively, and the VAS scores of C group at 3, 12 and 24 hours after operation were (2.35±0.75)points, (1.74±0.46)points and (1.18±0.26)points, respectively, which were decreased significantly compared with those of A group at the same time point [(3.35±0.59)points, (3.18±0.46)points and (3.01±0.33)points] (Fbetween group=7.02, Pbetween group<0.01; Ftime point=5.42, Ptime point=0.02; Fbetween group·time point=0.39, Pbetween group·time point=0.68). There was statistically significant difference among the three groups (χ2=7.66, P<0.05). The analgesic satisfaction of C group (91.67%) was significantly higher than that of A group (58.33%) and B group (62.50%) (χ2=5.44, 4.25, all P<0.05).@*Conclusion@#The sedative and analgesic effects of PCIA nabuprofen combined with sufentanil for patients with THA are definite and comfortable, which can effectively alleviate pain, so it has a definite clinical application value.