Effect of Qutan-Tongyang decoction on cardiac function and myocardial remodeling in patients with chronic heart failure / 国际中医中药杂志

ABSTRACT

Objective@#To explore the effect of Qutan-Tongyang decoction on cardiac function and myocardial remodeling in patients with chronic heart failure.@*Methods@#According to the random table method, 96 patients with chronic heart failure were divided into the control group (n=48) and the research group (n=48). The patients in the control group were treated with conventional treatment, and the patients in the research group were treated with Qutan-Tongyang decoction on the basis of the control group. Two groups of patients were treated for 4 weeks. The clinical total effective rate of two groups of patients after treatment was counted. The LVESD, LVEDD, LVEF, IVST, LVPWT, LVMI, BNP, Ang2 were determined respectively before and after treatment. In addition, the adverse reaction incidence of two groups of patients were observed.@*Results@#The total effective rate of research group was 89.58% (43/48), while the total effective rate of control group was 72.92% (35/48), the difference between two groups was statistically significant (χ2=4.376, P=0.036). After treatment, the LVESD (45.12 ± 3.02 mm vs. 48.05 ± 3.11 mm, t=4.683), LVEDD (52.24 ± 3.65 mm vs. 56.79 ± 4.15 mm, t=5.704), IVST (7.13 ± 0.63 mm vs. 8.02 ± 0.71 mm, t=6.496), LVPWT (8.15 ± 0.58 mm vs. 8.62 ± 0.75 mm, t=3.434), LVMI (97.65 ± 6.28 g/m2 vs. 112.26 ± 8.47 g/m2, t=9.600), BNP (120.21 ± 19.87 ng/L vs. 188.95 ± 24.18 ng/L, t=15.217), Ang2 (252.52 ± 53.74 pg/ml vs. 330.39 ± 60.85 pg/ml, t=6.645) of the research group were significantly lower than those of the control group (P<0.05), while the LVEF (46.79% ± 3.88% vs. 41.52% ± 3.04%, t=7.407) of the research group were significantly higher than the control group (P<0.05). During treatment, there was no significantly difference of adverse reaction rates of the two groups (χ2=0.545, P=0.460).@*Conclusions@#The clinical curative effect of Qutan-Tongyang decoction on the basis of conventional treatment for the treatment of chronic heart failure is significantly, which can significantly improve cardiac function and inhibit cardiac remodeling. It has the high security of the curative effect.