Roles and mechanisms of chemokine CX3CL1 in cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 706-710, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-798238
ABSTRACT
Chemokine CX3CL1 mainly participates in the physiological and pathological processes of nervous system by activating its receptor CX3CR1. Under physiological conditions, CX3CL1 can inhibit the activation of microglia; when cerebral ischemia and hypoxia, CX3CL1 can affect the expression of multiple downstream target genes involved in activation of adenosine receptor, inhibition of Ca2+ influx, and promotion of blood vessel growth. It is of great significance to improve the energy metabolism disorder and to establish microcirculation around infarcts after cerebral ischemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2019
Type:
Article
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