Anti-apoptotic mechanism of heme oxygenase 1 and its protective role in related ophthalmopathy / 中华实验眼科杂志

ABSTRACT

Heme oxygenase 1 (HO-1) is a stress response protein, and its anti-apoptosis research becomes a new hot spot.In recent years, HO-1 plays an important protective role in ophthalmopathy.HO-1 is a rate-limiting enzyme of heme catabolism, which can catalyze the transformation of heme to bilirubin, carbon monoxide and free iron.HO-1 is the main effector molecule of anti-apoptosis.The biological characteristics and anti apoptosis mechanism of HO-1 were elaborated and the research progress of HO-1 in corneal diseases, glaucoma, cataract, uveitis, Graves ophthalmopathy, diabetic retinopathy, retinitis pigmentosa and related mechanisms, which were related to anti-apoptosis, were reviewed.