Meta-analysis on effectiveness of live attenuated influenza vaccine against seasonal influenza in children / 中华流行病学杂志

ABSTRACT

Objective@#To evaluate the effectiveness of live attenuated influenza vaccine (LAIV) in the prevention of seasonal influenza in children aged 2-17 years.@*Methods@#Literature retrieval of case-control studies on the effectiveness of LAIV against seasonal influenza in children published from January 2003 to November 2018 was conducted through Web of Science, PubMed, and ScienceDirect databases. The Stata 13.1 software was used for Meta-analysis.@*Results@#A total of 14 studies were included in this study, and all were test-negative design (TND) studies. Our Meta-analysis showed that the effectiveness of LAIV in children was 49% (95%CI 40%-57%). Subgroup analysis found that the protection rate of LAIV was 35% against influenza A (H1N1) pdm09 (95%CI 5%-56%), 35% against influenza A (H3N2) (95%CI 21%-46%), and 71% against influenza B (95%CI 55%-82%). The protection rates of trivalent LAIV and quadrivalent LAIV in children were 56% (95%CI 48%-63%) and 44% (95%CI 27%-57%), respectively. The protection rates of LAIV in Europe and North America were 65% (95%CI 47%-77%) and 46% (95%CI 36%-55%), respectively.@*Conclusion@#LAIV has a certain preventive effect on seasonal influenza in children aged 2-17 years.