The Effect of Low Dose i.v. Ketamine in Combination with Epidural Morphine on Postoperative Pain / 대한마취과학회지
Korean Journal of Anesthesiology
; : 81-85, 2005.
Article
in Ko
| WPRIM
| ID: wpr-79907
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The purpose of this study was to evaluate the effect of low dose i.v. ketamine in combination with epidural morphine on postoperative pain after gastrectomy. METHODS: 40 patients scheduled for elective gastrectomy were investigated in a randomized study. All patients received epidural morphine (0.05 mg/kg) and bupivacaine (0.25%) as a bolus dose of 10 ml 40 min prior to skin incision. In addition, patient- controlled epidural analgesia (PCEA) with epidural bupivacaine (0.125%) and morphine (0.1 mg/ml) (bolus dose 1 ml, continuous infusion 1 ml/h, lock out interval 15 min) was offered from the time after 10 ml bolus dose. In the ketamine group, ketamine 0.5 mg/kg was administered 10 min prior to skin incision and then maintained continuously until skin closure at a dosage of 10microgram/kg/min. In the second group anesthesia was induced with thiopental sodium 4 mg/kg, midazolam 0.5 mg/kg, vecuronium 0.1 mg/kg and maintained with 66% N2O-O2, 1-3 vol% enflurane. The intensities of spontaneous pain and of coughing associated pain were measured using a visual analogue scale. Cumulative morphine consumption was measured at 2, 6, 12, 24, 48 h after surgery. Side effects were evaluated at 48 h after surgery. RESULTS: VAS and cumulative morphine consumption at 2, 6, 12, 24, 48 h postoperatively showed no statistical differences between the two groups, and no statistical differences in side effects were observed at 48h after surgery. CONCLUSIONS: We were unable to demonstrate any additional analgesic effect of low dose i.v. ketamine in combination with epidural morphine and bupivacaine.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pain, Postoperative
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Skin
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Thiopental
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Midazolam
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Vecuronium Bromide
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Bupivacaine
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Analgesia, Epidural
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Cough
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Enflurane
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Gastrectomy
Type of study:
Clinical_trials
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2005
Type:
Article