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Correlation between serum visfatin level and cardiovascular disease risk factors in patient with polycystic ovary syndrome / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine ; (36): 6-10, 2020.
Article in Chinese | WPRIM | ID: wpr-799149
ABSTRACT
Objective@#To explore the correlation between serum visfatin level and cardiovascular disease risk factors in patient with polycystic ovary syndrome (PCOS).@*Methods@#A total of 100 PCOS patients (PCOS group) and 50 healthy women (control group) in Wuhan Puren Hospital from July 2016 to July 2018 were selected. In addition, according to the body mass index (BMI), the PCOS patients were divided into obese group (BMI ≥ 25 kg/m2, 57 cases) and non-obese group (BMI < 25 kg/m2, 43 cases). Serum level of visfatin was measured by enzyme-linked immunosorbent assay (ELISA) method, and the correlation between serum visfatin and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testesterone (T), high sensitivity C-reactive protein (hs-CRP), blood lipids and blood glucose was analyzed.@*Results@#Compared with those in control group, the visfatin, BMI, diastolic blood pressure, waist and hip rate, hirsutism F-G score, FSH, LH, T, triglyeride (TG), fasting insulin (FINS), homeostasis model of assessment for insulin resistance index (HOMA-IR) in PCOS group were significantly increased (103.20 ± 19.15) μg/L vs. (29.56 ± 4.14) μg/L, (25.81 ± 4.17) kg/m2 vs. (21.29 ± 3.74) kg/m2, (81.91 ± 10.32) mmHg (1 mmHg = 0.133 kPa) vs. (68.29 ± 7.57) mmHg, 0.91 ± 0.14 vs. 0.82 ± 0.13,(13.41 ± 2.91) scores vs. (5.98 ± 1.01) scores, (12.78 ± 1.98) U/L vs. (11.95 ± 1.51) U/L, (15.84 ± 3.16) U/L vs. (12.94 ± 1.53) U/L, (2.98 ± 0.32) nmol/L vs. (1.17 ± 0.20) nmol/L, (1.89 ± 0.43) mmol/L vs. (1.21 ± 0.11) mmol/L, (18.40 ± 2.98) mU/L vs. (11.23 ± 2.10) mU/L, 4.25 ± 0.86 vs. 2.51 ± 0.55; the high density lipoprotein-cholesterol (HDL-C) and ISI were significantly decreased (1.46 ± 0.23) mmol/L vs. (1.55 ± 0.27) mmol/L and 0.011 ± 0.002 vs. 0.019 ± 0.005, and there were statistical differences (P<0.01 or <0.05). In addition, compared with those in non-obese group, the visfatin, BMI, diastolic blood pressure, hirsutism F-G score, FSH, LH, T, hs-CRP and TG in obese group were significantly higher, the HDL-C in obese group were significantly lower, and there were statistical differences (P<0.01 or <0.05). In PCOS group, serum visfatin level was positively correlated with BMI, diastolic blood pressure, hirsutism F-G score, FSH, LH, T, hs-CRP and TG, and serum visfatin level was negatively correlated with HDL-C (P<0.05). Stepwise multiple linear regression analysis showed that diastolic blood pressure and TG increased were the main predictors of increased visfatin level in patients with PCOS (P < 0.05).@*Conclusions@#Serum visfatin is increased in the patients with PCOS, and serum visfatin is positively related with the cardiovascular risk factors.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Postgraduates of Medicine Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Postgraduates of Medicine Year: 2020 Type: Article