Analysis of influencing factors associated with responsiveness to terlipressin in septic shock patients / 中国基层医药

ABSTRACT

Objective@#To determine the relevant factors associated with the responsiveness of terlipressin in patients with septic shock.@*Methods@#From June 2013 to June 2018, the clinical data of patients with septic shock in the intensive care unit (ICU) of the Affiliated Hospital of Hangzhou Normal University who received catecholamine and treated with terlipressin for at least 6 h, were retrospectively analyzed.Then, the patients were categorized as either responders or non-responders according to their responsiveness to terlipressin.The potential associations between some clinical indicators before the addition of terlipressin and responsiveness to terlipressin were analyzed.@*Results@#A total of 132 patients with septic shock were included in this study, including 60cases(45.45%) responders and 72cases(54.54%) non-responders.Compared with responders, non-responders had significantly higher ICU mortality and hospital mortality (ICU mortality 20.00% vs.72.22%, χ2=35.734, P<0.001; hospital mortality 81.67% vs.94.44%, P=0.028) and higher median blood lactate (2.73 mmol/L vs.5.22 mmol/L, Z=3.181, P=0.001). Multivariate logistic regression analysis showed that blood lactate level before the addition of terlipressin was a risk factor for patients with no response to terlipressin (odds ratio 1.130, 95% confidence interval 1.05-1.23, P=0.002). Receiver operating characteristic curve showed that the area under the curve of blood lactate before the addition of terlipressin was 0.661.@*Conclusion@#Blood lactate levels may be useful in predicting terlipressin responsiveness in patients with septic shock.