Pathogenesis and management of non-alcoholic fatty liver disease in children / 国际儿科学杂志

ABSTRACT

Non-alcoholic fatty liver disease(NAFLD)refers to a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis, which in turn can evolve into cirrhosis and end stage of liver disease.With the prevalence of childhood obesity worldwide, obesity and its related complications have become important factors endangering children′s health.As a manifestation of metabolic syndrome in the liver, NAFLD has become one of the most common liver diseases in children.Its occurrence and development may be the result of genetic susceptibility, genetic polymorphism, obesity, insulin resistance, cytokines, intestinal flora imbalance and other factors.Current treatments for NAFLD include lifestyle changes, medications, and surgery.This article reviews the epidemic trend, possible pathogenesis and treatment progress of NAFLD in children.