Association between thyroid hormones and visceral fat area in the patients with type 2 diabetes / 中华内分泌代谢杂志

ABSTRACT

Objective@#To explore the association between thyroid hormones and visceral fat area(VFA) in the patients with type 2 diabetes.@*Methods@#A total of 729 patients with type 2 diabetes, who joined National Metabolic Management Center(MMC) through Ningbo First Hospital from March, 2018 to July, 2019, were enrolled in this study. Blood tests were taken to assess their thyroid hormones and biochemical indexes. VFA and subcutaneous fat area(SFA) were obtained through bioelectrical impedance analysis. Statistics were later analyzed by Spearman correlation analysis and multivariate linear regression.@*Results@#Spearman correlation analysis showed that VFA were positively correlated with T3、FT3(r=0.225 and 0.211, P<0.01), and VFA were inversely correlated with FT4(r=-0.112, P<0.01). No correlation was found between VFA and either of T4 or TSH(P>0.05). Multivariate linear regression analysis indicated that VFA was independently correlated with FT4 and FT3(P<0.01). An increment of 1 pmol/L in FT4 was associated with 1.759 cm2 increase in VFA, and increment of 1 pmol/L in FT3 was associated with 3.256 cm2 decrease in VFA.@*Conclusion@#VFA in patients with type 2 diabetes are correlated with FT3 and FT4.