Clinical analysis of rightzopiclone on improvement of sleep disorders in patients with alzheimer's disease / 中国医师进修杂志

ABSTRACT

Objective@#To observe and analyze rightzopiclone on the improvement of sleep disorders in patients with Alzheimer disease.@*Methods@#Eighty-four Alzheimer disease patients with sleep disorders admitted to the Department of Neurology of the Dalian University Affiliated Xinhua Hospital from August 2016 to August 2018 were selected and randomly divided into observation group and control group, with 42 patients in each group. The patients in the observation group were given rightzopiclone orally, while the patients in the control group were given alprazolam orally. The Pittsburgh Sleep Quality Index (PSQI) was applied to assess the sleep state of the two groups before and after the treatment.@*Results@#The total effective rates of sleep improvement in the observation group were 78.57% and 92.86% after 2 and 4 weeks of the treatment, which was significantly higher than that in the control group of 54.76% and 73.81% (P<0.05), and the PSQI assessment results were also significantly better than those in the control group (P<0.05).@*Conclusions@#Rightzopiclone is helpful for the improvement of sleep state of Alzheimer disease patients with sleep disorders, and it has high clinical application value.