Your browser doesn't support javascript.
loading
Observe on the clinical value of ultrasound in the evaluation of the progress and curative effect of knee osteoarthritis / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 150-154, 2020.
Article in Chinese | WPRIM | ID: wpr-799638
ABSTRACT
Objective@#To explore the clinical value of ultrasound in evaluating the progress and curative effect of knee osteoarthritis, and its correlation with the changes of inflammation and bone metabolism.@*Methods@#30 patients with advanced knee osteoarthritis who were admitted to the Department of Ultrasound, Wenzhou Hospital of Traditional Chinese Medicine, Zhejiang University of Traditional Chinese Medicine from October 2017 to March 2019 were enrolled as non-acute knee osteoarthritis.30 cases of early knee osteoarthritis were included in the same period.Both groups received peripheral blood and musculoskeletal ultrasound on the morning and the 7th and 14th day after admission.The two groups were compared before treatment and treatment.The changes in serum (C-reactive protein) Hs-CRP, (interleukin-6) IL-6 levels in musculoskeletal ultrasound and inflammatory disease activity markers after 7 days of treatment, bone metabolism markers osteocalcin (OC), C Terminal peptide (CTX), and the correlation between serum CTX, OC, Hs-CRP, IL-6 levels and musculoskeletal ultrasound scores in patients with acute knee osteoarthritis.@*Results@#The serum CTX, OC, Hs-CRP and IL-6 levels in the advanced osteoarthritis of knee group CTX[(27.11±3.24)ng/L, (15.98±1.96)ng/L, ( 2.56±1.17)ng/L], OC[(15.47±6.33)mg/L, (11.27±4.14)mg/L, (9.43±2.82)mg/L], Hs-CRP[(14.95±1.44)mg/L, (9.89±1.23)mg/L、(6.26±0.55)mg/L], IL-6[(2.73±0.31)ng/L, (1.38±0.13)ng/L, (1.21±0.25)ng/L]were higher than those in the Early osteoarthritis of knee group before treatment and 7 days and 14 days after treatment CTX[(5.29±1.96 )ng/L, (4.38±1.64 )ng/L, (3.91±1.85 )ng/L], OC[(6.24±1.54)mg/L, (5.62±1.06)mg/L, (5.57±1.40)mg/L], Hs-CRP[(5.78±1.17)mg/L, (4.62±1.02)mg/L, (3.73±0.94)mg/L], IL-6[(0.17±0.15)ng/L, (0.15±0.03)ng/L, (0.15±0.14)ng/L](t=26.634, 8.646, 8.365, 22.256, 7.326, 11.065, 26.945, 6.295, 7.18, 41.433, 6.763, 21.773, all P<0.05). The serum CTX, OC, Hs-CRP and IL-6 levels in the acute knee osteoarthritis group were significantly lower than those before treatment (F=8.262, 7.873, 18.353, 21.45, all P<0.05), non-acute knee There was no significant difference in the above indexes between the osteoarthritis group and the serum at each time point(all P>0.05). The ultrasound score of musculoskeletal in the acute knee osteoarthritis group (9.12±4.27) was higher than that in the non-acute knee osteoarthritis group (3.57±1.82) (t=7.333, P<0.05); serum of patients with acute knee osteoarthritis The levels of CTX, OC, Hs-CRP and IL-6 were positively correlated with the musculoskeletal scores (R2 were 0.848, 0.828, 0.821 and 0.831, respectively, P<0.05).@*Conclusion@#The levels of serum CTX, OC, hs CRP and IL-6 increased with the progress of knee osteoarthritis, and decreased with the prolongation of the time after treatment.The ultrasonic score of knee joint was positively correlated with the changes of the above indexes, and decreased significantly after treatment.The ultrasonic score of knee joint has a certain clinical value in evaluating the condition and curative effect of knee osteoarthritis.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article