Research progress in cell repair of spinal cord injury / 中华创伤杂志

ABSTRACT

The mechanism of cell transplantation in repairing spinal cord injury mainly include replacing damaged neurons, protecting host neurons, preventing apoptosis, promoting axon regeneration and synapse formation, promoting myelination and secreting nutritional factors to improve microenvironment. A variety of cells have been used to repair spinal cord injury in animal models with certain effects, but the repair effect on complete injury is not obvious. Due to the difficulty in repairing spinal cord injury and the complexity of high-quality clinical studies, there lacks safe and effective comprehensive treatment method to maximize the improvement and recovery of patients' motor function. In order to summarize the research progress of cell therapy in the treatment of spinal cord injury and promote the in-depth study in this field, this article reviews various cell repair methods for spinal cord injury in aspects of their current status, safety and effectiveness and discusses the prospects of cell repair of spinal cord injury.