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Analysis of MRI radiomic features of hypoxic area in nasopharyngeal carcinoma patients / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology ; (6): 924-927, 2019.
Article in Chinese | WPRIM | ID: wpr-800193
ABSTRACT
Objective@#To analyze the magnetic resonance imaging (MRI) radiomic performance of hypoxic area in nasopharyngeal carcinoma patients, aiming to provide a reference for identification and analysis of hypoxic area.@*Methods@#The MRI-T1, MRI-T2, MRI-T1+ and PET/CT images of 32 patients initially diagnosed with nasopharyngeal carcinoma were retrospectively analyzed. The gross tumor volume (GTV) of nasopharynx was countoured and the hypoxic areas (GTV-H) were identified by 18F-FMISO-PET images. The non-hypoxic areas (GTV-NH) were defined as the rest of areas removed GTV-H from GTV. The radiomic features of GTV-H and GTV-NH were extracted and compared.@*Results@#The average volume of GTV-H and GTV-NH was (10.92±11.02) cm3 and (7.21±5.70) cm3, respectively. The maximum rate of change was 46% for intensity direct-global min (ID-GM) on MRI-T1(P<0.05, AUC>0.7 and Youden index>0.5). The average rate of change was 136% for long run emphasis (LRE), long run high gray level emphasis (LRHGLE) and long run low gray level emphasis (LRLGLE) on MRI-T2(P<0.05, AUC>0.7 and Youden index>0.5). The high change rates was greater than 90% on MRI-T1+ (P<0.05, AUC>0.7 and Youden index>0.5) for ID-GM, LRE, LRHGLE and LRLGLE.@*Conclusions@#The hypoxic area of tumor target can be reflected by MRI radiomics on T1/T2/T1+ . Quantifying and tracking the variations of these features can bring benefit to recognize the hypoxic area of nasopharyngeal carcinoma tumor target.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Radiation Oncology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Radiation Oncology Year: 2019 Type: Article